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Related Experiment Video

Updated: May 15, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

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Published on: December 18, 2016

First-onset functional brief psychoses in the elderly.

Yoram Barak1, Daniel Levy, Henry Szor

  • 1Abarbanel Mental Health Center, Bat-Yam ; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Canadian Geriatrics Journal : CGJ
|December 20, 2012
PubMed
Summary

Diagnoses of nonorganic psychosis in the elderly are common. Many patients experience diagnostic shifts, requiring flexible treatment approaches for late-life psychosis.

Keywords:
Psychosiselderlyoutcomeprogression

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Area of Science:

  • Geriatric Psychiatry
  • Psychopathology
  • Clinical Neuroscience

Background:

  • The origin and diagnostic classification of psychotic disorders emerging in late life are not well-established.
  • Understanding the diagnostic trajectory of these conditions is crucial for effective clinical management.

Purpose of the Study:

  • To assess the diagnostic stability of brief psychotic disorders with onset in elderly individuals.
  • To investigate the long-term diagnostic outcomes for late-life psychosis.

Main Methods:

  • A 10-year retrospective analysis of medical records was conducted.
  • Included were elderly patients (≥65 years) experiencing their first episode of psychosis.
  • Organic psychoses were excluded, focusing on nonorganic diagnoses.

Main Results:

  • Out of 2,072 elderly admissions, 604 met criteria for brief psychotic disorder.
  • The study included 83 patients (mean age 75.4 years) with a mean follow-up of 27.7 months.
  • Most common initial diagnoses were unspecified nonorganic psychosis (n=71), followed by persistent delusional disorder (n=10).
  • Frequent outcomes at follow-up included very late-onset schizophrenia-like psychosis and transitions to other brief psychotic disorders.

Conclusions:

  • Nonorganic psychosis presenting in late life is a significant clinical issue in tertiary care settings.
  • Diagnostic evolution is more prevalent than previously thought, necessitating adaptive diagnostic and treatment strategies for elderly patients with psychosis.