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Related Experiment Video

Updated: May 15, 2026

Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples
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Validated LC-MS/MS Panel for Quantifying 11 Drug-Resistant TB Medications in Small Hair Samples

Published on: May 19, 2020

Development and validation of a tuberculosis medication adherence scale.

Xiaoxv Yin1, Xiaochen Tu, Yeqing Tong

  • 1School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Plos One
|December 20, 2012
PubMed
Summary

A new Tuberculosis (TB) medication adherence scale (TBMAS) was developed and validated. This tool effectively identifies TB patients with poor adherence and potential causes, improving treatment outcomes.

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Area of Science:

  • Public Health
  • Clinical Pharmacy
  • Epidemiology

Background:

  • Medication adherence is crucial for Tuberculosis (TB) treatment success.
  • Existing tools are insufficient for identifying non-adherent TB patients and their reasons.
  • A validated scale is needed to improve TB medication adherence.

Purpose of the Study:

  • To develop and validate a Tuberculosis (TB) medication adherence scale (TBMAS).
  • To identify TB patients with poor adherence and potential causes.
  • To enhance TB treatment outcomes through improved adherence monitoring.

Main Methods:

  • A 41-item scale was initially designed and pilot-tested.
  • Validated in 438 TB patients using pharmacy refill records as external criteria.
  • Internal consistency, reliability, and validity were assessed using statistical analyses.

Main Results:

  • The final 30-item TBMAS explained 65% of cumulative variance.
  • Demonstrated high reliability (Cronbach's alpha 0.87, test-retest 0.83, split-half 0.85).
  • Achieved a positive predictive value of 65.5% and sensitivity of 82.9% for identifying non-adherents at a cut-off of 113.

Conclusions:

  • The TBMAS is a reliable and valid tool for identifying TB patients with poor adherence.
  • The scale helps in understanding potential causes of non-adherence.
  • TBMAS can contribute to targeted interventions for improving medication adherence in TB patients.