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Decrease of total antioxidative capacity in developed low cardiac output syndrome.

Alper Sami Kunt1, Mehmet Halit Andac

  • 1Özel Yaşam Hastanesi Life Hospital, Antalya, Turkey. dralper@msn.com

Oxidative Medicine and Cellular Longevity
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Total antioxidant capacity (TAC) significantly decreases during coronary artery bypass graft (CABG) surgery, especially in patients developing low cardiac output syndrome (LCOS). This finding may help predict LCOS development.

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Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Biochemistry

Background:

  • Cardiac surgery is known to induce oxidative stress.
  • Persistent oxidative stress during reperfusion can lead to depressed myocardial function and low cardiac output syndrome (LCOS).
  • Total antioxidant capacity (TAC) measures oxidative stress in tissues.

Purpose of the Study:

  • To investigate differences in TAC during coronary artery bypass graft (CABG) operations.
  • To compare TAC levels between patients who developed LCOS and those who did not.

Main Methods:

  • Seventy-nine patients undergoing CABG were enrolled.
  • Central venous blood samples were collected before, during, and after surgery to assess TAC.
  • Clinical data on demographics and outcomes were prospectively collected.

Main Results:

  • Low cardiac output syndrome (LCOS) developed in 10.12% of patients.
  • A significant decrease in TAC was observed during operation in LCOS patients compared to non-LCOS patients (P < 0.001).
  • The receiver operating characteristic (ROC) curve analysis yielded an area of 0.879.

Conclusions:

  • TAC decreases during isolated CABG surgery, particularly in patients who develop LCOS.
  • This decline in TAC may indicate intraoperative issues or insufficient myocardial antioxidant defense.
  • Routine TAC measurement during surgery could aid in assessing LCOS risk.