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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

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Related Experiment Videos

Osteoporosis.

Jeri W Nieves1, Michelle Mosner, Shari Silverstein

  • 1nievesj@helenhayeshosp.org

The New York State Dental Journal
|December 21, 2012
PubMed
Summary

Osteoporosis weakens bones, increasing fracture risk. Prevention involves lifestyle changes, bone density testing, and medical treatments, highlighting the importance of dental health awareness.

Area of Science:

  • Orthopedics and Endocrinology
  • Public Health and Preventive Medicine

Background:

  • Osteoporosis is a prevalent skeletal disorder defined by diminished bone strength, significantly elevating fracture risk.
  • Fractures associated with osteoporosis carry substantial morbidity and mortality, underscoring the critical need for effective prevention strategies.

Purpose of the Study:

  • To review the diagnosis, risk factors, and management of osteoporosis.
  • To emphasize the importance of osteoporosis awareness among dental professionals due to the association between dental and skeletal health.

Main Methods:

  • Review of current literature on osteoporosis diagnosis and management.
  • Assessment of lifestyle factors, diagnostic tools (risk assessment, bone density testing), and therapeutic options.
  • Examination of the relationship between oral health and systemic bone health.

Related Experiment Videos

Main Results:

  • Adequate calcium and vitamin D intake, physical activity, smoking cessation, and moderation of alcohol consumption are key for bone health.
  • Bone density testing and risk factor assessment are crucial for diagnosing osteoporosis.
  • Several FDA-approved medications are available for osteoporosis treatment.

Conclusions:

  • Fracture prevention is paramount in managing osteoporosis.
  • Osteoporosis management requires a multi-faceted approach including lifestyle modifications and medical interventions.
  • The link between dental health and osteoporosis necessitates increased awareness and understanding among dental practitioners regarding osteonecrosis of the jaw (ONJ).