Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

Inhibitors of Viral Protein Synthesis

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

Viral Hepatitis I: Introduction

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

Subviral Agents

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...

Viruses with RNA Genomes

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Oral Jewelry and Piercing: Risks to Health.

The New York state dental journal·2018

Same journal

Resective or Regenerative Periodontal Therapy: Considerations during Treatment Planning: A Case Report.

The New York state dental journal·2018

Same journal

Effect of Molding Technique on Iwo Physical Properties of Acrylic Resin Specimens.

The New York state dental journal·2018

Same journal

A Comparison of Three Camera Systems for Intraoral Photography.

The New York state dental journal·2018

Same journal

Eagle Syndrome: Case Report.

The New York state dental journal·2018

Same journal

Clinical and Radiographic Examination of Endoscopically Controlled Indirect Sinus Lift: An In vivo Study.

The New York state dental journal·2018

Search research articles

Related Experiment Video

Updated: May 15, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Antiviral agents and hepatitis C.

Maureen Archer-Festa¹, Susan Nilsen-Kupsch

¹Marcher@citytech.cuny.edu

The New York State Dental Journal

|December 21, 2012

Summary

Hepatitis C infection can lead to serious liver disease. New antiviral drugs offer treatment options for Hepatitis C genotype 1, but immediate post-exposure therapy is not recommended for dental workers.

Area of Science:

Hepatology
Virology
Infectious Diseases

Background:

Hepatitis C is a primary cause of chronic liver disease, cirrhosis, liver cancer, and liver transplantation.
A significant percentage of infected individuals develop a chronic carrier state, often remaining asymptomatic.

Purpose of the Study:

To review the implications of Hepatitis C infection and current treatment protocols.
To highlight newly approved antiviral agents for Hepatitis C genotype 1.

Main Methods:

Literature review of Hepatitis C epidemiology and treatment.
Analysis of current post-exposure protocols for healthcare workers.

Main Results:

Two new direct-acting antiviral agents, boceprevir and telaprivir (protease inhibitors), are FDA-approved for Hepatitis C genotype 1.

More Related Videos

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Related Experiment Videos

Last Updated: May 15, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Current protocol advises against immediate post-exposure therapy for Hepatitis C in dental healthcare workers.

Conclusions:

Dental healthcare workers exposed to Hepatitis C should undergo periodic testing.
Antiviral therapy should be offered if a chronic carrier state develops post-exposure.