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Precocious pubarche in Thai children

Somchit Jaruratanasirikul1, Maethanee Thaiwong

  • 1Department of Pediatrics, Faculty of Medicine, Prince of Songkla University Hat Yai, Songkhla, Thailand. somchit.j@psu.ac.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|December 21, 2012
PubMed

Insights

Precocious pubarche in young Thai children is often caused by congenital adrenal hyperplasia (CAH). Early investigation is crucial to identify underlying pathological causes like CAH.

Area of Science:

  • Pediatric Endocrinology
  • Reproductive Health
  • Endocrine Disorders

Background:

  • Precocious pubarche, the early development of pubic hair, requires thorough evaluation in children.
  • Understanding the diverse etiologies is essential for appropriate diagnosis and management.

Purpose of the Study:

  • To investigate the causes, clinical features, and laboratory findings in young Thai children presenting with precocious pubarche.
  • To determine the prevalence of different etiologies and identify key diagnostic markers.

Main Methods:

  • Retrospective review of medical records for 41 children evaluated for precocious pubarche between 1995 and 2011.
  • Analysis of clinical data, anthropometric measurements, and hormonal assays.

Main Results:

  • Congenital adrenal hyperplasia (CAH) was the most frequent etiology (46.3%), followed by isolated premature adrenarche (29.3%).
  • Pathological etiologies were associated with significantly greater weight and height compared to isolated premature adrenarche.
  • Elevated 17-hydroxyprogesterone levels indicated CAH, while higher DHEAS levels suggested adrenocortical carcinoma.

Conclusions:

  • Precocious pubarche in Thai children warrants investigation for underlying pathological conditions.
  • Congenital adrenal hyperplasia is the predominant pathological cause requiring prompt diagnosis and treatment.
Abstract

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