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Updated: May 15, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Vaccination using peptides spanning the SYT-SSX tumor-specific translocation
Jordan E Bloom1, Douglas G McNeel, Brian M Olson
1University of Wisconsin Carbone Cancer Center, 1111 Highland Avenue, Madison, WI 53705, USA.
This study evaluated a SYT-SSX breakpoint peptide vaccine for synovial sarcoma. The vaccine did not elicit a robust immune response, though some patients showed stable disease when treated with adjuvant and interferon-alpha.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Genetic translocations are key tumor-initiating events.
- Antigen-specific vaccines target tumor-specific breakpoint regions.
- SYT-SSX translocation is pathognomonic for synovial sarcoma.
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