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Updated: May 15, 2026
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
MMP-9 -1562C>T contributes to periodontitis susceptibility
Yongchu Pan1, Dandan Li, Qi Cai
1Institute of Stomatology, Nanjing Medical University, Nanjing, China.
Aim:
The study was conducted to explore the potential association of Matrix metalloproteinases (MMP)-9 -1562C>T with susceptibility to periodontitis.
Materials And Methods:
Electronic literature searches of PubMed, EMBASE and EBSCO databases were performed. Fixed-effects or random-effects models were used to calculate the pooled odds ratios (ORs) for four genetic comparisons.
Results:
Seven eligible studies with a total of 628 cases and 689 controls were recruited in the pooled analysis. We found MMP-9 -1562C>T contributed to decreased risk of chronic periodontitis. Furthermore, the polymorphism was associated with modified risk of periodontitis among Caucasian populations.
Conclusions:
This study indicated that MP-9 -1562C>T might be involved in the development of periodontitis. A replication of our results in independent large analysis populations is necessary to give evidence to our observation.
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