[Changes in blood coagulation and fibrinolysis following endoscopic injection sclerotherapy]

Changes in blood coagulation and fibrinolysis were investigated in twenty seven patients with esophageal varices, who underwent endoscopic injection sclerotherapy (EIS) with 5% ethanolamine oleate with meglumine amidotrioate (EOMA), 1% Aethoxyskererol (AS) and pure ethanol. Changes in platelet aggregation between before and just after EIS were also investigated. Results obtained were as follows. 1) Remarkable changes in blood coagulation and fibrinolysis were observed in twenty patients, who underwent EIS by intravariceal injection combined with paravariceal injection. The patients showed significant change in factor XIa-alpha 1 antitrypsin complex as a result of destruction of the endothelium of varices, caused by the sclerosants. On the other hand, no significant changes were observed in seven patients, treated by paravariceal injection alone. 2) These changes were different from those observed in DIC because they were transient without bleeding tendency or multiple organ failures. 3) Paravariceal injection was suitable for EIS in the patients with very poor liver function. 4) Platelet aggregation was not elevated by EIS.