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Updated: May 15, 2026
12:27
Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
Published on: June 16, 2023
Intermittent or continuous occlusion of hepatic inflow.
M Radojkovic1, M Stojanovic, G Stanojevic
1Surgery Department, University of Nish, Nish, Serbia. milan.radojkovic@medfak.ni.ac.rs
Bratislavske Lekarske Listy
|December 21, 2012
Summary
Intermittent inflow occlusion better protects the liver from ischemia/reperfusion (I/R) injury than continuous occlusion. Continuous clamping caused more severe liver damage, as shown by biochemical and histopathological analyses.
Area of Science:
- Hepatology
- Surgical Research
- Experimental Pathology
Background:
- Liver ischemia/reperfusion (I/R) injury is a significant clinical challenge.
- Understanding the impact of different vascular occlusion methods is crucial for optimizing surgical outcomes.
Purpose of the Study:
- To compare the efficacy of intermittent versus continuous inflow occlusion in mitigating liver I/R injury.
- To evaluate the protective effects of intermittent Pringle maneuver in an experimental model.
Main Methods:
- Wistar rats underwent either continuous or intermittent inflow liver vascular occlusion.
- Serum biochemical markers (ALT, AST, LDH, ALP, albumin) and liver histopathology were analyzed.
Main Results:
- Continuous occlusion led to significantly higher serum ALT, AST, and LDH levels.
- Continuous occlusion resulted in lower ALP activity and albumin concentration.
- Histopathological examination revealed more severe liver damage with continuous occlusion.
Conclusions:
- Continuous hepatic pedicle clamping causes more significant parenchymal damage compared to intermittent clamping.
- The liver demonstrates better tolerance to intermittent Pringle maneuver, suggesting its superiority in reducing I/R injury.
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