Related Experiment Video
Updated: May 15, 2026
11:27
Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
Published on: April 29, 2014
Perifosine in renal cell carcinoma
Neeharika Srivastava1, Daniel C Cho
1Beth Israel Deaconess Medical Center, Division of Hematology and Oncology, 330 Brookline Avenue, MASCO 4th Floor, Boston, MA 02215, USA.
Expert Opinion on Investigational Drugs
|December 21, 2012
Summary
Perifosine shows clinical activity in advanced renal cell carcinoma (RCC) but is not superior to existing treatments as a single agent. Combination therapy with other targeted agents may offer a future role for perifosine in RCC treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Perifosine, an oral alkylphospholipid, targets advanced renal cell carcinoma (RCC).
- It inhibits Akt activation by preventing cell membrane localization via its PH domain.
Purpose of the Study:
- To review the therapeutic landscape of RCC.
- To evaluate the role, mechanism, efficacy, and safety of perifosine in advanced RCC.
Main Methods:
- Literature review of RCC therapeutic landscape.
- Summary of perifosine's mechanism of action, pharmacodynamics, pharmacokinetics, clinical efficacy, and safety in RCC.
Main Results:
- Perifosine demonstrates clinical activity in advanced RCC.
- It is not superior to current single-agent therapies for RCC.
Conclusions:
- Perifosine is not recommended as a single agent for further development in RCC.
- Its efficacy and mild toxicity suggest potential utility in combination with other targeted agents for RCC therapy.
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