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Perifosine in renal cell carcinoma

Neeharika Srivastava1, Daniel C Cho

  • 1Beth Israel Deaconess Medical Center, Division of Hematology and Oncology, 330 Brookline Avenue, MASCO 4th Floor, Boston, MA 02215, USA.

Expert Opinion on Investigational Drugs
|December 21, 2012
PubMed
Abstract

Insights

Perifosine shows clinical activity in advanced renal cell carcinoma (RCC) but is not superior to existing treatments as a single agent. Combination therapy with other targeted agents may offer a future role for perifosine in RCC treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Perifosine, an oral alkylphospholipid, targets advanced renal cell carcinoma (RCC).
  • It inhibits Akt activation by preventing cell membrane localization via its PH domain.

Purpose of the Study:

  • To review the therapeutic landscape of RCC.
  • To evaluate the role, mechanism, efficacy, and safety of perifosine in advanced RCC.

Main Methods:

  • Literature review of RCC therapeutic landscape.
  • Summary of perifosine's mechanism of action, pharmacodynamics, pharmacokinetics, clinical efficacy, and safety in RCC.

Main Results:

  • Perifosine demonstrates clinical activity in advanced RCC.
  • It is not superior to current single-agent therapies for RCC.

Conclusions:

  • Perifosine is not recommended as a single agent for further development in RCC.
  • Its efficacy and mild toxicity suggest potential utility in combination with other targeted agents for RCC therapy.

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