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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 15, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon.

Rosalia Maglietta1, Vania Cosma Liuzzi, Elisa Cattaneo

  • 1Istituto di Studi sui Sistemi Intelligenti per l'Automazione - CNR, Via Amendola 122/D-I, 70126 Bari, Italy.

BMC Cancer
|December 21, 2012
PubMed
Summary

Analyzing molecular pathways in colorectal tumors reveals key changes during progression. This study identifies specific gene expression alterations driving malignant transformation from preinvasive to invasive stages.

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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Related Experiment Videos

Last Updated: May 15, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • Colorectal cancer (CRC) development involves progressive molecular and morphological changes in precancerous lesions.
  • Analyzing preinvasive tumors of varying sizes offers insights into the sequence of these alterations.

Purpose of the Study:

  • To investigate molecular pathway alterations during colorectal tumorigenesis.
  • To identify specific pathways driving progression from preinvasive to invasive stages.

Main Methods:

  • Transcriptomic profiling of 59 colorectal tumors across early preinvasive, late preinvasive, and invasive stages.
  • Utilized a molecular pathway-based approach with random set analysis to identify differentially regulated genes and enriched pathways compared to normal mucosa.

Main Results:

  • 112 out of 880 canonical pathways showed significant tumor-related dysregulation.
  • Early preinvasive stage: DNA replication stress, cell-cycle checkpoint activation, and suppressed transmembrane signaling.
  • Late preinvasive stage: Downregulated differentiation pathways, altered cell cycle (G2>M), and nuclear envelope dynamics.
  • Invasive stage: Activated cell cycle (G1>S), upregulated pro-tumorigenic factors, and metabolic pathway dysregulation (aerobic glycolysis).

Conclusions:

  • Specific pathway dysregulations are associated with distinct transitions in colorectal tumorigenesis.
  • This study provides a systems biology-based molecular characterization of colorectal cancer development.
  • The findings offer a foundation for further research into CRC molecular mechanisms.