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Collagen sealant patch to reduce lymphatic drainage after lymph node dissection.

Gianluca Di Monta1, Corrado Caracò, Anna Crispo

  • 1Department of Surgery, Melanoma, Soft Tissues, Head and Neck, Skin Cancers, National Cancer Institute of Naples, Naples, Italy. gidimonta@libero.it

World Journal of Surgical Oncology
|December 21, 2012
PubMed
Summary

This study found that using a collagen sealant patch (CSP) significantly reduced postoperative drainage duration in patients undergoing radical lymph node dissection for metastatic melanoma. The CSP group experienced shorter drainage periods compared to standard treatment alone.

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Area of Science:

  • Surgical Oncology
  • Melanoma Treatment
  • Wound Management

Background:

  • Seroma formation is a common complication after radical lymph node dissection (RLND) in metastatic melanoma patients.
  • Prolonged drainage increases morbidity and healthcare costs.
  • Fibrin sealants are explored as a preventative strategy.

Purpose of the Study:

  • To evaluate the efficacy of a fibrinogen/thrombin-coated collagen sealant patch (CSP) in reducing postoperative drainage duration.
  • To compare outcomes between standard treatment and standard treatment plus CSP in patients undergoing RLND.

Main Methods:

  • Prospective, single-center study.
  • Randomized patients undergoing axillary or ilio-inguinal RLND into two groups: standard treatment alone or standard treatment plus CSP.

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  • Primary endpoint: postoperative duration of drainage.

    • Main Results:

    • Mean drainage duration was significantly reduced in the CSP group (20.1 days) compared to the standard treatment group (23.3 days) (p=0.010).
    • A higher percentage of patients in the CSP group were drainage-free by day 21 (86%) versus the standard group (67%) (p=0.049).
    • Study included 70 patients undergoing axillary (n=47) or ilio-inguinal (n=23) RLND.

    Conclusions:

    • The collagen sealant patch significantly decreases the duration of postoperative drainage following RLND.
    • Further research is needed to validate these findings across different lymphadenectomy types.