Apical ballooning syndrome in first degree relatives
Vijayakumar Subban1, Sivakumar Ramachandran, Suma M Victor
1Department of Cardiology, Institute of Cardiovascular Diseases, Madras Medical Mission, Tamil Nadu, India. drvijay1977@yahoo.com
Indian Heart Journal
|December 21, 2012
Summary
Apical ballooning syndrome, or Takotsubo cardiomyopathy, is a stress-related heart condition. A mother and daughter presenting simultaneously suggests a potential genetic link for this unusual cardiomyopathy.
Area of Science:
- Cardiology
- Genetics
- Internal Medicine
Background:
- Apical ballooning syndrome (Takotsubo cardiomyopathy) is a stress-induced, reversible heart condition.
- It predominantly affects postmenopausal women, but its genetic basis remains unclear.
Observation:
- A 68-year-old mother and her 43-year-old daughter were admitted concurrently with acute chest pain.
- Both patients experienced symptoms following the death of a close relative.
- Clinical presentation and recovery were typical for Takotsubo cardiomyopathy in both individuals.
Findings:
- The simultaneous presentation of Takotsubo cardiomyopathy in a mother and daughter is a rare occurrence.
- This familial clustering suggests a potential inherited predisposition to the condition.
Implications:
- This case highlights the possibility of a genetic component influencing susceptibility to Takotsubo cardiomyopathy.
- Further research into genetic factors may aid in understanding and potentially predicting risk for this cardiac abnormality.
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