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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Bone remodelling in inflammatory arthritis.

Steven R Goldring1, P Edward Purdue, Tania N Crotti

  • 1Research Division, Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, 535 East 70th Street, New York, NY 10128, USA. goldrings@hss.edu

Annals of the Rheumatic Diseases
|December 21, 2012
PubMed
Summary
This summary is machine-generated.

Inflammatory arthropathies like rheumatoid arthritis and lupus cause bone changes around joints. This review explores cellular and molecular reasons for differing bone remodeling patterns in these conditions.

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Area of Science:

  • Rheumatology
  • Orthopedics
  • Immunology

Background:

  • Inflammatory arthropathies significantly alter peri-articular bone structure.
  • Distinct patterns and progression of skeletal changes are observed across different inflammatory arthritis types.

Purpose of the Study:

  • To review recent advances in understanding the cellular and molecular mechanisms driving differential bone remodeling in inflammatory arthritis.
  • To elucidate the factors contributing to varied skeletal manifestations in rheumatoid arthritis, seronegative spondyloarthropathies, and systemic lupus erythematosus.

Main Methods:

  • Literature review of recent research on cellular and molecular mechanisms.
  • Analysis of studies focusing on bone remodeling in inflammatory arthropathies.
  • Synthesis of findings related to inflammation site and inflammatory tissue products.

Main Results:

  • Inflammation site and inflammatory tissue properties influence bone remodeling patterns.
  • Specific cellular and molecular pathways contribute to differential bone loss or formation.
  • Understanding these mechanisms is key to explaining disease-specific skeletal changes.

Conclusions:

  • Differential bone remodeling in inflammatory arthropathies is driven by complex cellular and molecular interactions.
  • Further research into these mechanisms can inform targeted therapeutic strategies.
  • The interplay between inflammation and bone metabolism varies significantly among rheumatoid arthritis, seronegative spondyloarthropathies, and systemic lupus erythematosus.