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Updated: May 15, 2026
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Different prognosis of acute myeloid leukemia harboring monosomal karyotype with total or partial monosomies
Ewa Wawrzyniak1, Agnieszka Wierzbowska, Aleksandra Kotkowska
1Department of Hematology, Medical University, Lodz, Poland. ewa.wawrzyniak@umed.lodz.pl
Abstract:
A monosomal karyotype (MK) was identified by banding techniques (BT) in acute myeloid leukemia (AML). However, BT may be insufficient to determine the actual loss of a complete chromosome, especially in complex karyotypes. We have investigated the effect of monosomy type, total (MK-t) and partial (MK-p), reevaluated by FISH, on prognosis. We have found that complete remission rate and probability of overall survival at 1 year was higher in MK-p (n=27) than MK-t (n=15) group (40% vs. 15.4%, P=0.19 and 30% vs. 9%, P=0.046, respectively). Our results indicate for the first time that monosomy type influences the prognosis of MK-AML.
