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Updated: May 15, 2026

Primary Culture of Porcine Retinal Pigment Epithelial Cells

Primary Culture of Porcine Retinal Pigment Epithelial Cells

Published on: September 23, 2022

Reticulate pigmentary disorders.

Kabir Sardana¹, Khushbu Goel, Shikha Chugh

¹Department of Dermatology, Maulana Azad Medical College, Delhi, India.

Indian Journal of Dermatology, Venereology and Leprology

|December 21, 2012

Summary

This summary is machine-generated.

Reticulate pigmentary disorders encompass various conditions with net-like or freckle-like patterns. This review proposes "mottled pigmentation" as a unifying term for these and related dyschromasias.

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Last Updated: May 15, 2026

Primary Culture of Porcine Retinal Pigment Epithelial Cells

Primary Culture of Porcine Retinal Pigment Epithelial Cells

Published on: September 23, 2022

Area of Science:

Dermatology
Genetics
Pigmentary Disorders

Background:

Reticulate pigmentary disorders lack a clear definition and consistent classification in major textbooks.
Existing terminology is varied, leading to confusion among different morphologies and causes.

Purpose of the Study:

To harmonize the classification of reticulate pigmentary disorders.
To propose a unifying term, "mottled pigmentation," encompassing acquired and congenital conditions.
To focus on inherited reticulate pigmentary disorders in this review.

Main Methods:

Literature review focusing on inherited reticulate pigmentary disorders.
Analysis of current classifications and terminology.
Discussion of genetic loci and clinical distribution patterns.

Main Results:

Reticulate pigmentary disorders present with diverse morphologies, from reticular to freckle-like patterns.
Genetic reticulate pigmentary disorders often involve keratin 5/14 gene loci.
Clinical classification based on regional distribution (facial, truncal, acral, flexural) is proposed as useful.

Conclusions:

The term "mottled pigmentation" is suggested to unify reticulate pigmentary disorders, dyschromasias, and reticular pattern disorders.
Classification can be based on genetic loci or clinical distribution.
Further harmonization of terminology is needed for clarity in reticulate pigmentary disorders.