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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Genome guardian p53 and viral infections
Yoshitaka Sato1, Tatsuya Tsurumi
1Division of Virology, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.
Abstract:
Because virus infections elicit various cellular responses that inhibit viral replication and growth, viruses must intervene to attenuate antiviral measures in order to thrive. The genome guardian p53 plays a central part not only in DNA damage responses, inducing cell cycle arrest or apoptosis, but also in the innate host immune control of viral infections by orchestrating diverse signaling pathways originating from many different cellular receptors and sensors. Many viruses have acquired sophisticated mechanisms to regulate p53 functions by deploying subversive proteins and modulating its post-transcriptional status. In this review, we overview the mechanisms by which DNA and RNA viruses manage p53 signaling in favor of their continued survival.
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