Related Experiment Video
Updated: May 15, 2026
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Effect of second dose of measles vaccine on measles antibody status: a randomized controlled trial
Anjum Fazilli1, Abid Ali Mir, Rohul Jabeen Shah
1Departments of Community Medicine, Microbiology and Pediatrics, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, J and K, India.
Insights
A second measles vaccine dose significantly boosts antibody levels in children compared to a single dose. This enhanced immunity is crucial for long-term protection against measles infection.
Area of Science:
- Immunology
- Vaccinology
- Pediatrics
Background:
- Measles remains a significant public health concern globally.
- Assessing optimal vaccination schedules is vital for achieving herd immunity.
- The effectiveness of a second measles vaccine dose in specific pediatric populations requires further investigation.
Purpose of the Study:
- To evaluate the impact of a second measles vaccine dose on measles antibody status in children.
- To compare measles-specific antibody titers between children receiving one versus two doses of the measles vaccine.
Main Methods:
- A randomized controlled trial was conducted at a tertiary hospital's immunization center.
- Children aged 6-17 years, including those with obesity and metabolic abnormalities, were enrolled.
- Blood samples were analyzed for measles IgG antibody titers before and after vaccination, with a second dose administered to the study group.
Main Results:
- The study group receiving a second measles vaccine dose showed a significant increase in protective measles IgG antibody titers (93.3%) compared to the control group (50%).
- The Geometric Mean Titer (GMT) of measles IgG increased in the study group post-second dose, while it decreased in the control group.
- Baseline protective antibody levels were observed in 36.6% of the study group and 43.3% of the control group.
Conclusions:
- A second dose of the measles vaccine effectively boosts measles antibody status in children.
- This finding supports the recommendation for a two-dose measles vaccination schedule for enhanced and sustained immunity.
Objective:
To evaluate the effect of the second dose of measles vaccine on measles antibody status during childhood.
Setting:
Immunization centre of Under-five Clinic of the Department of Community Medicine at a tertiary-hospital.
Study Design:
Randomized Controlled trial.
Subjects:
Children from 6 years to 17 year old. 188 with simple obesity, and 431 with obesity and metabolic abnormalities. 274 age and gender-matched healthy children as controls.
Methods:
Blood samples were collected from all subjects for baseline measles serology by heel puncture at 9-12 months of age. All subjects were given the first dose of measels vaccine. At second visit (3-5 months later), after collecting the blood sample from all, half the children were randomized to receive the second dose of measles vaccine (study group), followed by collection of the third sample six weeks later in all the subjects.
Results:
A total of 78 children were enrolled and 30 children in each group could be analyzed. 11(36.6%) children in the study group and 13 (43.3%) children in the control group had protective levels of measles IgG at baseline. Around 93.3% of children in the study group had protective measles antibody titers as against 50% in the control group at the end of the trial. The Geometric Mean Titre (GMT) of measles IgG increased from 14.8 NTU/mL to 18.2 NTU/mL from baseline to six weeks following receipt of the second dose of the vaccine in the study group, as compared to a decrease from 16.8 NTU/mL to 12.8 NTU/mL in the control group.
Conclusion:
A second dose of measles vaccine boosts the measles antibody status in the study population as compared to those who receive only a single dose.
Related Concept Videos
01:51Vaccinations
01:23Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...