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Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions
Andriana I Papaioannou1, Christos Rossios, Konstantinos Kostikas
13rd Respiratory Medicine Department, Sismanogleio General Hospital, Athens, Greece. papaioannouandriana@gmail.com
Current Drug Targets
|December 22, 2012
Summary
Chronic obstructive pulmonary disease (COPD) involves accelerated lung aging. This review summarizes aging mechanisms in COPD and potential therapies targeting them.
Area of Science:
- Pulmonology
- Gerontology
- Molecular Biology
Background:
- Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a condition of accelerated lung aging.
- COPD prevalence and lung function decline are strongly associated with age, particularly in smokers.
Purpose of the Study:
- To review the mechanisms driving accelerated lung aging in COPD.
- To explore potential therapeutic strategies targeting these aging pathways.
Main Methods:
- Literature review of studies on COPD pathogenesis and aging.
- Analysis of molecular and cellular mechanisms implicated in accelerated lung aging.
- Examination of therapeutic interventions targeting aging pathways in COPD.
Main Results:
- Key aging mechanisms in COPD include oxidative stress, inflammation, and telomere shortening.
- Reduced anti-aging molecules (sirtuins, Nrf-2) and altered pathways (mTOR, Klotho) are observed in COPD lungs.
- Several therapeutic interventions targeting these mechanisms have been investigated and some are in clinical trials.
Conclusions:
- Accelerated lung aging is a significant factor in COPD development and progression.
- Targeting specific aging mechanisms offers promising therapeutic avenues for COPD treatment.
- Further research and clinical trials are needed to validate these anti-aging strategies for COPD.
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