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Does hemochromatosis predispose to celiac disease? A study of 29,096 celiac disease patients

Jonas F Ludvigsson1, Joseph A Murray, Paul C Adams

  • 1Department of Paediatrics, Örebro University Hospital, Sweden. jonasludvigsson@yahoo.com

Scandinavian Journal of Gastroenterology
|December 22, 2012
PubMed

Insights

Hereditary hemochromatosis (HH) appears to increase the risk of celiac disease (CD). This population-based study found a significant association between these two conditions, highlighting a potential link for further research.

Area of Science:

  • Gastroenterology
  • Genetics
  • Epidemiology

Background:

  • Case reports suggest a link between hereditary hemochromatosis (HH) and celiac disease (CD).
  • Quantitative estimates of this association are currently lacking in population-based studies.

Purpose of the Study:

  • To estimate the association between HH and CD using a population-based study design.
  • To investigate the risk of CD in individuals diagnosed with HH.

Main Methods:

  • A case-control study was conducted using biopsy reports from all Swedish pathology departments.
  • 29,096 individuals with biopsy-verified CD (Marsh stage III) were identified.
  • The risk of HH diagnosis in CD patients was compared to 144,522 matched controls using conditional logistic regression.

Main Results:

  • Hereditary hemochromatosis was observed in 30 patients with CD and 60 matched controls.
  • HH was associated with an increased risk of CD, with an odds ratio (OR) of 2.30 (95% CI = 1.53-3.45).
  • Restricting HH to individuals with at least two records, the OR for CD was 2.54 (95% CI = 1.57-4.11), and when HH preceded CD diagnosis, the OR was 2.64 (95% CI = 1.24-5.60).

Conclusions:

  • Hereditary hemochromatosis is associated with an increased risk of developing celiac disease.
  • The findings suggest a significant link between these two conditions that warrants further investigation.
Abstract

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