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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Straightforward synthesis of a double-lasso macrocycle from a nonsymmetrical [c2]daisy chain
Camille Romuald1, Guillaume Cazals, Christine Enjalbal
1Supramolecular Machines and Architecture Team, Institut des Biomolécules Max Mousseron, IBMM, UMR 5247 CNRS - UM1-UM2, Université Montpellier 2, Place Eugène Bataillon, case courrier 1706, F-34095 Montpellier Cedex 5, France.
Abstract:
The straightforward synthesis of a double-lasso macrocycle from a nonsymmetrical [c2]daisy chain, using the copper(I)-catalyzed Huisgen alkyne-azide 1,3-dipolar cycloaddition, is described. The preparation of the nonsymmetrical alkyne azide [c2]daisy chain precursor was realized in situ via the exchange of the monomers contained in both symmetrical alkyne and azide [c2]daisy chains and was followed by mass spectrometry.
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