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Updated: May 15, 2026
Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain
Shyam Kaulaskar1, Pravinkumar Bhutada, Anand Rahigude
1Post-Graduate Research Department, Sinhgad College of Pharmacy, Pune 411041, Maharashtra, India.
Objective:
To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain.
Methods:
After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured.
Results:
Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione.
Conclusion:
The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.
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