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Updated: May 15, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

[Apoptosis-inducing effect of annexin A2 on multiple myeloma cells and its related mechanisms]

Hong-Yu Bao1, Jian-Ning Wang, Yan-Qiu Hou

  • 1Department of Hematology, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210011, Jiangsu Province, China. baohongyu74@yahoo.com.cn

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|December 22, 2012
PubMed

Insights

Silencing the Annexin A2 gene (AnxA2) promotes apoptosis in multiple myeloma cells. This study reveals AnxA2

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Biology

Context:

  • Multiple myeloma (MM) is a cancer of plasma cells.
  • Understanding novel therapeutic targets is crucial for MM treatment.
  • Annexin A2 (AnxA2) role in MM pathogenesis requires further investigation.

Purpose:

  • To investigate the apoptosis-inducing effect of Annexin A2 (AnxA2) on multiple myeloma (MM) cells.
  • To elucidate the underlying mechanisms of AnxA2-mediated apoptosis in MM.

Summary:

  • Human MM cell lines (U266, RPMI8226) were transfected with siRNA targeting AnxA2.
  • AnxA2 gene silencing significantly increased apoptosis in MM cells (P < 0.05).
  • Silencing AnxA2 modulated apoptosis-related gene expression, including down-regulation of p65NF-κB, IL-2, IL-6, and up-regulation of P53.

Impact:

  • AnxA2 gene silencing demonstrates a pro-apoptotic effect on MM cells.
  • This finding suggests AnxA2 as a potential therapeutic target for multiple myeloma.
  • Modulation of key signaling pathways (NF-κB, p53) is involved in AnxA2-mediated apoptosis.

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