Related Experiment Video
Updated: May 15, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Trafficking of regulatory T cells in the intestinal immune system
1Institute of Immunology, Hannover Medical School, Germany. Pabst.Oliver@MH-Hannover.de
Abstract:
Intestinal tolerance toward dietary antigens and the microbiota critically depends on regulatory T cells (T(reg) cells). To exert their function, T(reg) cells need to get into the proximity of their target cells foremost within lymphoid organs and the lamina propria in the small and large intestines. Thus, T(reg)-cell-mediated immunosuppression is intrinsically linked to cell migration and localization. However, the gut lamina propria not only constitutes an effector site but also actively influences T(reg)-cell function. In particular, gut-resident macrophages take an active role in shaping the T(reg)-cell pool. Here, the author summarizes recent observations to suggest that T(reg)-cell migration not only directs cells to sites of immunosuppression but also allows for the coordinated shaping of the T(reg)-cell population.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Bowel Disease III: Crohn's Disease
Renewal of Intestinal Stem Cells
Cell-mediated Immune Responses
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

