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Related Experiment Video

Updated: May 15, 2026

Intravital Video Microscopy Measurements of Retinal Blood Flow in Mice
10:16

Intravital Video Microscopy Measurements of Retinal Blood Flow in Mice

Published on: December 26, 2013

Retinal blood flow evaluation.

Constantin J Pournaras1, Charles E Riva

  • 1Department of Ophthalmology, Vitreo-Retinal Unit, Geneva University Hospitals, Geneva, Switzerland. constantin.pournaras @ lacolline.ch

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|December 22, 2012
PubMed
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Noninvasive optical and laser techniques now allow detailed study of human retinal blood flow regulation. These advanced methods offer new insights into vascular retinal diseases and their origins.

Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Physiology

Background:

  • Traditional knowledge of retinal blood flow relies on invasive animal studies.
  • Recent advancements in optics and lasers have enabled noninvasive human eye research.

Purpose of the Study:

  • To review noninvasive techniques for investigating retinal hemodynamics in humans.
  • To explore the regulation of retinal blood flow in response to physiological and pharmacological stimuli.

Main Methods:

  • Retinal Vessel Analyzer for dynamic diameter measurements.
  • Laser Doppler velocimetry for absolute velocity and blood flow calculation.
  • Laser Doppler flowmetry and speckle flowgraphy for microcirculation velocity mapping.
  • Blue-field simulation for leukocyte dynamics.

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Last Updated: May 15, 2026

Intravital Video Microscopy Measurements of Retinal Blood Flow in Mice
10:16

Intravital Video Microscopy Measurements of Retinal Blood Flow in Mice

Published on: December 26, 2013

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Retinal Pathophysiological Evaluation in a Rat Model
09:11

Retinal Pathophysiological Evaluation in a Rat Model

Published on: May 6, 2022

  • Color Doppler imaging for arterial blood velocity and resistivity index.

    • Main Results:

    • Noninvasive techniques simplify the measurement of retinal vessel diameter changes.
    • Absolute blood flow can be calculated in major retinal vessels.
    • Microcirculation and leukocyte behavior can be quantified.
    • Arterial blood flow parameters provide insights into vascular resistance.

    Conclusions:

    • Noninvasive optical and laser techniques provide comprehensive retinal hemodynamic assessment.
    • These methods enhance understanding of retinal vascular disease pathogenesis.
    • Further research can elucidate the role of altered retinal blood flow regulation in disease.