Related Experiment Video
Updated: May 15, 2026

Microfluidics-Assisted Selective Depolarization of Axonal Mitochondria
Published on: August 4, 2022
The influence of mitochondrial complex inhibition on neuronal ion channel and neurotransmitter release
1State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, China. laibin@fudan.edu.cn
Abstract:
Mitochondrial complex inhibition has been described in the pathophysiology of many neurodegenerative diseases, and the functional changes of neuron induced by mitochondrial complex inhibition and the mechanism are concerned. Neuronal function depends on action potentials and neurotransmitter release. Voltage dependent sodium/potassium ion channels mediate generation of neuron action potentials. And voltage dependent calcium ion channels are directly involved in the process of neurotransmitter release. The functional changes of those ion channels under some pathological conditions can induce neuron dysfunction, even death. Therefore, understanding the influence of mitochondrial complex inhibition on neuronal ion channels and neurotransmitter release is helpful to illuminate the pathophysiology of neurodegenerative diseases. This review will highlight recent progress in this field.
Related Concept Videos
Excitatory and Inhibitory Effects of Neurotransmitters
The Electron Transport Chain
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q in...
Neurochemical Transmission: Sites of Drug Action
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Drugs Affecting Neurotransmitter Synthesis
Ligand-Gated Ion Channel Receptor: Gating Mechanism

