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Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: May 15, 2026

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

Adipose stem cells and skeletal repair.

Gun-Il Im1

  • 1Department of Orthopaedics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea. gunil@duih.org

Histology and Histopathology
|December 22, 2012
PubMed
Summary

Adipose stem cells (ASCs) offer a plentiful source for bone tissue engineering, surpassing bone marrow stem cells due to easier harvesting. These cells show rapid osteogenic differentiation, making them ideal for repairing bone defects.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Stem Cell Biology

Background:

  • Adipose tissue, once deemed inert, is now recognized as a rich source of adult stem cells (ASCs).
  • ASCs possess significant osteogenic differentiation potential, crucial for bone regeneration.
  • Compared to bone marrow stem cells, ASCs are more abundant and harvestable with minimal patient morbidity.

Purpose of the Study:

  • To review the potential of adipose stem cells (ASCs) in bone tissue engineering.
  • To explore the osteogenic differentiation capabilities of ASCs.
  • To discuss advancements in scaffolding materials and in vivo models for adipose-derived bone regeneration.

Main Methods:

  • Review of current literature on adipose stem cells and osteogenic differentiation.

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Use of Human Perivascular Stem Cells for Bone Regeneration
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Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

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Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
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Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle
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FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle

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Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

  • Analysis of scaffolding materials suitable for adipose bone tissue engineering.
  • Evaluation of in vivo models for preclinical assessment.

    • Main Results:

    • Adipose tissue yields a greater quantity of stem cells than bone marrow.
    • ASCs demonstrate rapid and efficient osteogenic differentiation.
    • Various biomaterials are being investigated as scaffolds for ASC-based bone regeneration.

    Conclusions:

    • Adipose stem cells represent a promising and accessible cell source for bone tissue engineering.
    • Further research into scaffolding and in vivo models is essential for clinical translation.
    • ASCs offer a viable alternative for treating large bone defects and enhancing bone regeneration.