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Updated: May 15, 2026

Tissue Collection of Bats for -Omics Analyses and Primary Cell Culture
Published on: October 23, 2019
Comparative analysis of bat genomes provides insight into the evolution of flight and immunity
Guojie Zhang1, Christopher Cowled, Zhengli Shi
1BGI-Shenzhen, Shenzhen, 518083, China. zhanggj@genomics.org.cn
Abstract:
Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
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