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Related Experiment Video

Updated: May 15, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Dose selection in stereotactic radiosurgery.

John C Flickinger¹, Hideyuki Kano, Ajay Niranjan

¹Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA. flickingerjc@upmc.edu

Progress in Neurological Surgery

|December 22, 2012

Summary

This summary is machine-generated.

Selecting the right radiation dose for arteriovenous malformation (AVM) radiosurgery balances obliteration success with minimizing complication risks. This review covers principles and data for guiding AVM radiosurgery dose selection.

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Area of Science:

Neurosurgery
Radiation Oncology
Medical Physics

Background:

Arteriovenous malformation (AVM) radiosurgery requires careful dose selection to balance treatment efficacy and patient safety.
The prescription dose is critical for achieving AVM obliteration while minimizing risks of radiation-induced complications.
Predicting individual patient complication risks is challenging, influenced by treatment volume, location, and tissue characteristics.

Purpose of the Study:

To review the principles and data that guide the selection of prescription doses in AVM radiosurgery.
To provide a framework for physicians to optimize dose selection in AVM radiosurgery treatment planning.

Main Methods:

Review of existing literature and clinical data on AVM radiosurgery outcomes.
Analysis of factors influencing complication risks, including treatment volume, target location, and tissue type.
Synthesis of principles for balancing obliteration rates and complication avoidance.

Main Results:

Dose selection involves a trade-off between achieving high obliteration rates and limiting potential adverse effects.
Factors such as AVM size, location within the brain, and surrounding critical structures significantly impact complication risk.
Understanding dose-volume relationships and radiobiological principles is essential for informed decision-making.

Conclusions:

Optimal AVM radiosurgery dose selection requires a personalized approach based on patient-specific factors and treatment parameters.
This review synthesizes current knowledge to aid clinicians in making informed decisions regarding prescription doses for AVM radiosurgery.
Further research may refine predictive models for complication risks to enhance treatment personalization.