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Related Experiment Video

Updated: May 15, 2026

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
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Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

Biodegradable microparticles and nanoparticles by electrospraying techniques.

Vincenzo Guarino1, Wan Khartini Wan Abdul Khodir, Luigi Ambrosio

  • 1Institute of Composite and Biomedical Materials, National Research Council of Italy, Naples, Italy. vguarino@unina.it

Journal of Applied Biomaterials & Functional Materials
|December 22, 2012
PubMed
Summary
This summary is machine-generated.

Electrospraying creates biodegradable microparticles and nanoparticles for drug delivery. This technique controls particle size and shape, enabling advanced drug targeting and oral delivery applications.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Biodegradable microparticles and nanoparticles are increasingly utilized as carriers for targeted delivery of genes, drugs, and biomolecules.
  • Electrospraying is an advanced technique for preparing biodegradable particles with enhanced bioavailability, encapsulation efficiency, controlled release, and reduced toxicity.

Purpose of the Study:

  • To explore the benefits of electrospraying for controlling the morphology of biodegradable microparticles and nanoparticles.
  • To assess the potential of electrospraying in developing novel drug delivery systems.

Main Methods:

  • Chitosan and polycaprolactone (PCL) particles were fabricated using electrospraying.
  • Key process parameters, including voltage and flow rate, were meticulously controlled during particle fabrication.

Main Results:

  • Polycaprolactone (PCL) microparticles exhibited varied morphologies (spherical or flattened) influenced by solution concentration, affecting evaporation and chain entanglement.
  • Chitosan nanoparticles with submicrometric sizes were achieved by optimizing voltage and flow rate, demonstrating control over particle size and distribution.

Conclusions:

  • Electrospraying effectively controls the morphology of biodegradable microparticles and nanoparticles for drug delivery.
  • Integrating electrospraying with electrospinning offers new possibilities for developing innovative drug delivery devices, including those for tumor targeting and oral administration.