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A transcriptional blueprint for human and murine diabetic kidney disease

Vivek Bhalla1, Maria-Gabriela Velez, Glenn M Chertow

  • 1Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. vbhalla@stanford.edu

Diabetes
|December 22, 2012
PubMed
Abstract

No abstract available in PubMed .

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Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...