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Updated: May 15, 2026
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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Brain abnormalities in neuromyelitis optica spectrum disorder.
Woojun Kim1, Su-Hyun Kim, So-Young Huh
1Department of Neurology, The Catholic University of Korea, Seoul, Republic of Korea.
Multiple Sclerosis International
|December 22, 2012
Summary
Neuromyelitis optica spectrum disorder (NMOSD) can involve brain lesions, not just optic neuritis and myelitis. Advanced MRI techniques reveal these brain abnormalities and their associated symptoms.
Area of Science:
- Neuroimmunology
- Neurology
- Radiology
Background:
- Neuromyelitis optica (NMO) is an inflammatory central nervous system syndrome.
- NMO was historically considered to lack brain involvement.
- The discovery of NMO-IgG/aquaporin-4 antibody expanded the definition to NMOSD, recognizing brain lesions.
Purpose of the Study:
- To investigate the incidence and characteristics of brain lesions in NMOSD.
- To correlate brain lesions with clinical symptoms in NMOSD patients.
- To highlight the role of advanced imaging in detecting NMOSD brain abnormalities.
Main Methods:
- Review of recent literature on NMOSD brain lesions.
- Analysis of studies utilizing advanced neuroimaging techniques.
- Correlation of imaging findings with clinical presentations.
Main Results:
- Brain lesions are common in NMOSD and can be the initial manifestation.
- Characteristic brain lesion locations aid in NMOSD diagnosis.
- Advanced MRI techniques like DTI, MRS, and VBM reveal previously undetected brain abnormalities.
Conclusions:
- Brain involvement is a recognized feature of NMOSD.
- Diagnostic criteria and guidelines for NMOSD now incorporate brain abnormalities.
- Advanced imaging significantly enhances the understanding and diagnosis of NMOSD brain pathology.
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