[Present status and future prospects of antibody therapy against solid tumor]

Area of Science:

• Oncology and Immunology
• Molecular Biology

Context:

• Antibody-based therapies are increasingly utilized in oncology.
• Targeting strategies include cell surface antigens, growth factors, and signal transduction pathways.

Purpose:

• To review the role and impact of anti-tumor antibodies in cancer treatment.
• To highlight advancements in antibody targeting and their clinical outcomes.

Summary:

• Anti-tumor antibodies demonstrate significant efficacy across diverse tumor types, particularly when combined with cytotoxic drugs.
• Targeting strategies encompass cell surface differentiation antigens, growth factors, growth factor receptors, and signal transduction factors.
• Clinical benefits include improved response rates and prolonged progression-free survival (PFS) and overall survival (OS), with some antibodies establishing new treatment standards.

Impact:

• Antibody therapies have revolutionized cancer care, offering improved patient outcomes.
• Challenges remain in patient selection and understanding the precise mechanisms of action for certain immunotherapies like ipilimumab.