Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Suicide Deaths Among Hospitalized Patients With Delirium: A Case Series From a Nationwide Database in Japan.

International journal of psychiatry in medicine·2026

Same author

Subcutaneous Emphysema and Postoperative Complications in Robot-Assisted Gastrectomy: Impact of a Lower-Pressure Insufflation Strategy.

Asian journal of endoscopic surgery·2026

Same author

Catastrophic Esophageal Tumor Perforation within One Week after First-Line Chemo-Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma: A Case Report.

Surgical case reports·2026

Same author

Protocol for chromatin immunoprecipitation using isolated antheridia of Marchantia polymorpha.

STAR protocols·2026

Same author

Evocalcet improved the PTH-calcium setpoint and suppressed parathyroid proliferation in mice model of primary hyperparathyroidism.

Journal of bone and mineral metabolism·2026

Same author

A Case of Late Radiation-Induced Enteritis with Enterolith Caused Enterocutaneous Fistula.

Surgical case reports·2026

Search research articles

Related Experiment Video

Updated: May 15, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

[New directions in immunotherapy for malignant solid tumors].

Kiyotaka Okuno¹, Fumiaki Sugiura, Yasushi Sukegawa

¹Department of Surgery, Kinki University, Faculty of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|December 25, 2012

Summary

Advances in cancer vaccines and immunotherapy offer new hope against malignant solid tumors. This review covers progress and ongoing clinical trials for these promising targeted treatments.

More Related Videos

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Related Experiment Videos

Last Updated: May 15, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Area of Science:

Oncology
Immunology
Molecular Biology

Context:

Malignant solid tumors present significant therapeutic challenges.
Conventional treatments like chemotherapy and radiation have limitations in efficacy and toxicity.
Growing understanding of tumor molecular biology and tumor-immune interactions fuels novel therapeutic development.

Purpose:

To summarize recent advancements in cancer vaccine development.
To review immunotherapeutic approaches, including adoptive cell transfer.
To highlight ongoing Phase II/III clinical studies for malignant solid tumors globally.

Summary:

This article reviews the progress in developing novel cancer vaccines and immunotherapies.
It discusses targeted agents that leverage the tumor-immune system interaction.
Ongoing global Phase II/III studies for solid tumors are also examined.

Impact:

Highlights the potential of cancer vaccines and immunotherapy as effective treatments.
Provides an overview of the current landscape of advanced cancer therapies.
Informs about ongoing clinical research and future directions in oncology.