Related Experiment Video
Updated: May 15, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
[WT1-targeting cancer vaccine].
1Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 25, 2012
Summary
Wilms
Area of Science:
- Oncology and Immunology: Focuses on cancer biology and immune system interactions.
Context:
- The Wilms' tumor gene (WT1) encodes a transcription factor with oncogenic properties.
- WT1 protein is identified as a tumor-associated antigen, making it a target for cancer therapies.
Purpose:
- To evaluate the efficacy and safety of WT1 peptide-based immunotherapy.
- To explore the potential of WT1 immunotherapy as a novel cancer treatment strategy.
Summary:
- WT1 peptide-based immunotherapy has been administered to over 600 patients with leukemia and solid tumors.
- This immunotherapy demonstrates safety and clinical benefits, particularly in leukemia, glioblastoma multiforme, advanced pancreatic cancer, and ovarian cancer.
- The study suggests initiating WT1 immunotherapy before conventional treatments to target cancer stem cells.
Impact:
- WT1 immunotherapy shows promise as a safe and effective treatment option for various cancers.
- Early application of WT1 immunotherapy could enhance treatment outcomes by eradicating cancer stem cells.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...