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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: May 15, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

[Immunotherapy targeting cancer stem cells].

Yutaka Kawakami¹, Maiko Matsushita, Ryo Ueda

¹Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|December 25, 2012

Summary

Cancer stem cells (CSCs) resist chemotherapy and cause relapse. Immunotherapy targeting CSCs is promising, but their immunosuppressive abilities must be overcome for effective cancer treatment.

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Area of Science:

Oncology
Immunology
Cancer Stem Cell Biology

Background:

Cancer stem cells (CSCs) are implicated in tumor recurrence and resistance to conventional therapies.
Targeting CSCs is a critical strategy for improving cancer treatment outcomes.
Immunotherapy presents a potential avenue for eliminating CSCs.

Purpose of the Study:

To explore the potential of immunotherapy for eradicating cancer stem cells.
To identify tumor antigens expressed by CSCs for targeted immunotherapy development.
To investigate the immunosuppressive mechanisms employed by CSCs.

Main Methods:

Identification of tumor antigens specific to cancer stem cells.
Evaluation of immunotherapy strategies targeting these antigens.
Analysis of the immunosuppressive properties of cancer stem cells.

Main Results:

Tumor antigens expressed by CSCs have been identified.
Immunotherapy approaches targeting CSCs are under development.
CSCs possess immunosuppressive capabilities that may hinder treatment efficacy.

Conclusions:

Effective immunotherapy against cancer requires addressing CSCs.
Targeting CSC-specific antigens is a key strategy.
Overcoming CSC-mediated immunosuppression is crucial for successful cancer immunotherapy.