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Membranoproliferative glomerulonephritis complicating Waldenström's macroglobulinemia
David Kratochvil1, Kerstin Amann, Heike Bruck
1Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany
This case highlights an uncommon presentation of Waldenström's macroglobulinemia-associated glomerulonephritis, featuring significant glomerular proliferation and hyaline thrombi. The kidney injury was oligosymptomatic, underscoring the need for biopsy in diagnosing such rare conditions.
Area of Science:
- Nephrology
- Hematology
- Pathology
Background:
- Lymphoproliferative disorders can cause paraproteinemia and kidney injury via monoclonal immunoglobulin deposition.
- Waldenström's macroglobulinemia (WM) typically presents with intracapillary hyaline thrombi and minimal glomerular proliferation.
- This case presented atypical features of glomerulonephritis in a patient with WM.
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