The chromosome-centric human proteome project: a call to action

Area of Science:

• Proteomics
• Genomics
• Bioinformatics

Background:

• The Human Proteome Project (HPP) is a major international research effort.
• The Human Proteome Organisation (HUPO) has announced a new consortium for HPP.
• HPP aims to systematically characterize the human proteome.

Purpose of the Study:

• To establish a two-part HPP: B/D-HPP (biological/disease samples) and C-HPP (gene products).
• To identify and characterize at least one protein representative for every human gene.
• To create a protein distribution atlas and a protein pathway/network map.

Main Methods:

• Development of a two-part Human Proteome Project consortium (B/D-HPP and C-HPP).
• Systematic identification and characterization of proteins encoded by the human genome.
• Collaboration between academia and the Industrial Advisory Board (IAB) for tool development.

Main Results:

• Formation of the HPP consortium by HUPO.
• Commitment from the Industrial Advisory Board (IAB) to support C-HPP goals and milestones.
• Focus on developing essential tools, reagents, and workflows for the proteomics community.

Conclusions:

• The HPP is progressing towards its grand vision.
• The C-HPP, supported by the IAB, aims to create a trusted resource for future biological research.
• Collaboration is key to achieving ambitious goals in human proteome characterization.