Related Experiment Videos
Amoxicillin therapy for Chlamydia trachomatis in pregnancy
W R Crombleholme1, J Schachter, M Grossman
1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco.
Obstetrics and Gynecology
|May 1, 1990
Summary
Amoxicillin offers a well-tolerated alternative for treating pregnant women with Chlamydia trachomatis cervical infections. Patient compliance was significantly higher with amoxicillin compared to erythromycin due to fewer gastrointestinal side effects.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pharmacology
Background:
- Current Centers for Disease Control guidelines recommend erythromycin for Chlamydia trachomatis cervical infections in pregnancy.
- Gastrointestinal side effects of erythromycin can lead to compliance issues, necessitating alternative treatments.
Purpose of the Study:
- To compare the efficacy and patient compliance of amoxicillin versus erythromycin base for treating Chlamydia trachomatis cervical infections in pregnant women.
Main Methods:
- An open trial compared amoxicillin (500 mg TID for 7 days) with erythromycin base (500 mg QID for 7 days).
- Efficacy was assessed by negative cervical cultures post-treatment.
- Infant vertical transmission was evaluated via culture and antibody testing.
Main Results:
- Amoxicillin achieved a 98.4% cure rate versus 94.8% for erythromycin.
- No significant difference in infant vertical transmission rates was observed between groups.
- Significantly fewer patients discontinued amoxicillin due to side effects (2%) compared to erythromycin (13%).
Conclusions:
- Amoxicillin demonstrates comparable efficacy to erythromycin for treating Chlamydia trachomatis cervical infections in pregnancy.
- Amoxicillin offers improved patient compliance due to a lower incidence of gastrointestinal side effects.
- Amoxicillin may serve as an acceptable alternative treatment option.