Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction.

ChemMedChem·2024

Same author

Evaluating Scalable Supervised Learning for Synthesize-on-Demand Chemical Libraries.

Journal of chemical information and modeling·2023

Same author

Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1.

Biochemistry·2022

Same author

Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin.

MedChemComm·2019

Same author

Identification of 4-Amino-Thieno[2,3-<i>d</i>]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis.

mSphere·2019

Same author

A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings.

Nature communications·2019

Search research articles

Related Experiment Video

Updated: May 15, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

Approaches to virtual screening and screening library selection.

Scott A Wildman¹

¹Biochemistry and Molecular Biophysics, Washington University, 660 S. Euclid Ave, St. Louis, MO 63110, USA. wildman@biochem.wustl.edu

Current Pharmaceutical Design

|December 25, 2012

Summary

Virtual screening (VS) is increasingly used but often misused. This review highlights common virtual screening challenges to help researchers assess result reliability.

More Related Videos

A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

Published on: March 10, 2017

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

Published on: March 10, 2017

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Area of Science:

Computational chemistry
Drug discovery
cheminformatics

Background:

Virtual screening (VS) software accessibility has surged, leading to over 300 publications in the past year.
These publications focus on identifying new chemical matter and developing novel VS techniques.

Purpose of the Study:

To identify common difficulties in virtual screening (VS) applications.
To enable researchers to better evaluate the reliability of their VS efforts.

Main Methods:

Literature review of virtual screening publications.
Analysis of common challenges and misinterpretations in VS results.

Main Results:

Increased use of VS has led to a rise in its misuse and misinterpretation.
Several common pitfalls in VS methodology and result interpretation have been identified.

Conclusions:

Researchers must be aware of potential difficulties to ensure accurate virtual screening outcomes.
A critical assessment of VS reliability is essential for successful drug discovery and chemical matter identification.