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Updated: May 15, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
Published on: December 14, 2015
Blending hippo and WNT: sharing messengers and regulation
Becky P Tsai1, Nate P Hoverter, Marian L Waterman
1Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA.
Abstract:
Two new studies reveal ways in which the Wnt pathway commandeers Hippo components for signaling. Azzolin et al. show how the Hippo transcription factor TAZ mediates Wnt signals, and Rosenbluh et al. show how β-catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.
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