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Related Experiment Video

Updated: May 15, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

[Mechanisms underlying post-inflammatory hyperpigmentation: lessons from solar lentigo].

G Cardinali¹, D Kovacs, M Picardo

¹San Gallicano Dermatological Institute, IRCCS, Via Elio Chianesi 53, Rome 00144, Italie.

Annales De Dermatologie Et De Venereologie

|December 25, 2012

Summary

Postinflammatory hyperpigmentation (PIH) involves skin pigmentation changes due to inflammation. Fibroblast-derived growth factors, like keratinocyte growth factor (KGF), play a key role in PIH development.

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Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

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Last Updated: May 15, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Quantification of Hypopigmentation Activity In Vitro

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Area of Science:

Dermatology
Cell Biology
Molecular Biology

Context:

Hyperpigmentation is common in all skin types, particularly in individuals with darker skin tones.
Inflammation or injury can lead to pigmentation alterations (hyperpigmentation/hypopigmentation) in skin of color.
Postinflammatory hyperpigmentation (PIH) frequently occurs after conditions like acne, eczema, and contact dermatitis.

Purpose:

To investigate the role of fibroblast-derived growth factors in skin pigmentation and hyperpigmentation.
To explore the mechanisms of mesenchymal-epithelial cell interactions in regulating melanocyte function.
To understand the contribution of keratinocyte growth factor (KGF) to hyperpigmented lesions.

Summary:

Skin pigmentation is regulated by keratinocyte-melanocyte cross-talk and mesenchymal-epithelial cell interactions.
Fibroblast-derived growth factors, notably keratinocyte growth factor (KGF), are implicated in melanin deposition and hyperpigmentation.
Elevated KGF levels and receptor expression in solar lentigo suggest KGF's involvement in hyperpigmented spot formation.

Impact:

Highlights the critical role of fibroblast-derived growth factors in hyperpigmentation.
Provides insights into the cellular mechanisms underlying PIH in various skin conditions.
Suggests potential therapeutic targets for managing hyperpigmentation disorders.