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Updated: May 15, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Pneumocephalus as a cause of a decrease in the bispectral index]
J L Herreras Gutiérrez1, F Gilsanz Rodríguez1
1Servicio de Anestesia y Reanimación, Hospital Universitario La Paz, Madrid, España.
A patient experienced a sudden drop in bispectral index (BIS) after cerebellopontine angle tumor removal, likely due to pneumocephalus. Neurological function remained intact, and the patient recovered uneventfully with conservative management.
Area of Science:
- Neurosurgery
- Anesthesiology
- Neurology
Background:
- Cerebellopontine angle tumors often require complex surgical removal.
- General anesthesia necessitates continuous patient monitoring, including brain activity.
- Retrosigmoid access is a common surgical approach for these tumors.
Observation:
- A significant decrease in bispectral index (BIS) values was noted post-operatively.
- An increase in the brain's suppression rate correlated with the BIS decrease.
- The patient exhibited no overt neurological deficits despite the electrophysiological changes.
Findings:
- The observed electrophysiological changes were attributed to frontal pneumocephalus, a complication of air entering the cranial cavity.
- The bispectral index (BIS) values normalized, and the patient was successfully extubated.
- Conservative management, focusing on air reabsorption, was chosen by the neurosurgical team.
Implications:
- This case highlights the importance of monitoring brain activity during neurosurgery, even in the absence of clinical signs.
- Pneumocephalus can manifest with significant electrophysiological changes without immediate neurological impairment.
- Conservative management can be effective for managing post-operative pneumocephalus in select neurosurgical cases.
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