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Failure to acquire an inhibitory task following seizure-induced brain damage
T Harrigan1, O Peredery, M A Persinger
1Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.
Perceptual and Motor Skills
|February 1, 1990
Abstract:
Male rats that had displayed limbic seizures following a single pair of systemic injections of lithium and pilocarpine were trained 2 months later on an operant schedule that required differential low rates of responding (DRL). The seizured rats never acquired schedules that required either 6-sec. or 12-sec. inhibition of responses following a reward; these rats displayed more perseverative responding and shorter interresponse times than controls. Histomorphology indicated severe brain damage primarily within the entorhinal cortices (and adjacent amygdala) and dorsal thalamus.