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Updated: May 15, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
[The cooperation between p53 and Ras in tumorigenesis]
Yong-Yong Wei1, Jing Hou, Wen-Ru Tang
1Lab of Molecular Genetics of Aging and Tumor, School of medicine, Kunming University of Science and Technology, Kunming 650500, China. weiyong880201@sina.com
Tumor suppressor p53 and oncogene Ras mutations cooperate in cancer development. Their synergistic effects, including mutual regulation and gene control, are key to tumorigenesis and potential therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- p53 is a critical tumor suppressor gene, frequently mutated in ~50% of human cancers.
- Ras is a frequently mutated oncogene, found in 30-90% of human tumors.
- The interplay between p53 and Ras is crucial in the multistep process of tumorigenesis.
Purpose:
- To review the recent progress on the synergistic effects between p53 and Ras.
- To elucidate the cooperative mechanisms driving tumorigenesis.
- To highlight the implications for personalized cancer therapy.
Summary:
- The cooperative effects between tumor suppressor p53 and oncogene Ras are multifaceted.
- These include p53 regulating Ras function, Ras regulating p53, and their joint control over tumorigenesis-related genes.
- Understanding these interactions is vital for deciphering cancer mechanisms.
Impact:
- Provides insights into tumorigenesis driven by p53 inactivation and Ras activation.
- Facilitates the selection of pharmacological targets for cancer therapy.
- Aids in the development of personalized treatment strategies.
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