Antioxidant cosmeto-textiles: skin assessment

Area of Science:

• Dermatology and Cosmetology
• Materials Science
• Pharmacology

Background:

• Resveratrol, a natural antioxidant, shows potential for protecting skin from oxidative stress.
• Cosmeto-textiles are emerging as delivery systems for active cosmetic ingredients.
• Understanding percutaneous absorption is crucial for effective topical treatments.

Purpose of the Study:

• To evaluate the percutaneous absorption and antioxidant efficacy of resveratrol in pig skin.
• To compare resveratrol's efficacy with trolox, a Vitamin E analog.
• To assess resveratrol delivery from cosmeto-textiles to skin layers using in vitro and in vivo methods.

Main Methods:

• In vitro percutaneous absorption studies using pig skin.
• DPPH assay to evaluate free radical scavenging activity.
• In vivo skin stripping and in vitro permeation studies with cosmeto-textiles on human volunteers.

Main Results:

• Resveratrol was detected in all skin layers (stratum corneum, epidermis, dermis) after in vitro application.
• Resveratrol exhibited higher antioxidant efficacy (lower ED50) than trolox.
• Cosmeto-textiles delivered resveratrol to skin layers, acting as a sustained release system, though with lower penetration than direct application.

Conclusions:

• Resveratrol is a potent antioxidant with significant skin penetration capabilities.
• Cosmeto-textiles can serve as effective reservoirs for controlled release of resveratrol into the skin.
• These findings suggest a method to enhance the skin's inherent antioxidant capacity.