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Updated: May 15, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
NO inhibitory guaianolide-derived terpenoids from Artemisia argyi
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Abstract:
An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00μM.
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