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PAPP-A in cardiac and non-cardiac conditions

Yuehua Li1, Chenghui Zhou, Xianliang Zhou

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 25, 2012
PubMed

Insights

Pregnancy-associated plasma protein-A (PAPP-A) is a biomarker for heart disease and aging. It plays a role in atherosclerosis and may be a target for anti-aging therapies, impacting lifespan.

Area of Science:

  • Biochemistry
  • Cardiology
  • Gerontology

Background:

  • Pregnancy-associated plasma protein-A (PAPP-A) is a protease in the insulin-like growth factor (IGF) axis.
  • PAPP-A cleaves IGF binding proteins, releasing IGFs and influencing cellular processes.
  • It has emerged as a significant biomarker in various medical conditions.

Purpose of the Study:

  • To review the role of PAPP-A in cardiac and non-cardiac conditions.
  • To highlight PAPP-A's potential as a diagnostic biomarker and therapeutic target.
  • To explore PAPP-A's association with aging and disease progression.

Main Methods:

  • Literature review of studies on PAPP-A.
  • Analysis of PAPP-A's enzymatic function and biomarker utility.
  • Examination of PAPP-A's role in atherosclerosis, aging, and disease.

Main Results:

  • PAPP-A is crucial in progressive atherosclerosis and a biomarker for acute coronary syndrome.
  • It predicts all-cause mortality and cardiovascular events.
  • PAPP-A knockout mice exhibit extended lifespans, suggesting an anti-aging role.
  • PAPP-A is also linked to malignant cancer and end-stage renal disease.

Conclusions:

  • PAPP-A is a versatile biomarker with implications for cardiovascular health and aging.
  • Its role as a protease and its association with diverse diseases warrant further investigation.
  • PAPP-A presents a potential target for therapeutic interventions in aging and disease.

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