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Two different cardiomyopathies in a single patient : hypertrophic cardiomyopathy and left ventricular noncompaction

M Sunbul1, B Ozben, B Mutlu

  • 1Faculty of Medicine, Department of Cardiology, Marmara University, Yildiz Caddesi Konak Apartmani No: 43/16, 34353, Besiktas/Istanbul, Turkey.

Herz
|December 25, 2012
PubMed

Insights

This case study presents a rare instance of a 29-year-old man diagnosed with both hypertrophic cardiomyopathy and left ventricular noncompaction. It suggests a potential shared genetic cause or distinct mutations contributing to these distinct cardiac conditions.

Area of Science:

  • Cardiology
  • Genetics
  • Human Pathology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease causing left ventricular (LV) hypertrophy.
  • Left ventricular (LV) noncompaction is a rare cardiomyopathy with persistent fetal myocardium and distinct LV abnormalities.

Observation:

  • A 29-year-old male patient presented with co-occurring hypertrophic cardiomyopathy and LV noncompaction.
  • This unique case involves two distinct inherent cardiac conditions in the same individual.

Findings:

  • The coexistence of HCM and LV noncompaction in one patient is highly unusual.
  • The case highlights the complex genetic underpinnings of cardiomyopathies.

Implications:

  • This case suggests a potential common genetic mutation underlying both HCM and LV noncompaction.
  • Alternatively, the patient may harbor separate genetic mutations for each condition.
  • Further research into shared genetic pathways for cardiomyopathies is warranted.

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